Sporanox capsules

Onychomycosis is a fungal nail infection. In severe cases, oral antifungals are recommended as first-line agents. Oral triazole antifungals such as itraconazole (Sporanox capsules) as well as terbinafine (Lamisil tablets) are recommended. Treatment with itraconazole poses a lesser burden to patients... 

Itraconazole Sporanox capsule, oral 100 mg solution, oral 10 mg/ml injectable 10 mg/ml (generic also available)... 

Sporanox Capsules (Itraconazole). Janssen-Cilag Ltd, UK Summary of product characteristics, March 2004. 

Sporanox Capsules (Itiaccxiazole). Janssen. US Prescribir informaticxi, June 2006. 

In one study, either 240 mL of double-strength grapefruit juice or water were given with, and 2 hours after a single 200-mg dose of itraconazole (Sporanox capsules, Janssen) to 11 healthy subjects immediately after a standard breakfast. Grapefruit juice, unexpectedly decreased the AUC of itraconazole on average by 43% (range 81% reduction to 105% increase), with a similar decrease in hydroxy-itraconazole levels. However, another... 

The commercially available Sporanox capsule formulation is a solid dispersion relying on the principle of supersaturation to enhance the intestinal absorption of the antifungal itraconazole (ITR), a weak base (pKa = 4) with an extremely low and pH-dependent aqueous solubility (ca. 1 ng/mL in water, 6 mg/mL in 0.1 M HCl). This formulation comprises a molecular dispersion of ITR in a hydroxypropylmethyl-cellulose (HPMC) matrix, which is coated onto inert sugar spheres. Dissolution of HPMC in media simulating the gastric environment results in supersaturated concentrations which are maintained for at least 4 h. HPMC is believed to prevent ITR from precipitation in the stomach and in the intestine, resulting in significant absorption (maximum fraction absorbed ca. 85 %) and oral bioavailability (ca. 55 % Brewster et al. 2008). 

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