Split and mix combinatorial synthesis

An example of a 3x3x3 combinatorial split and mix combinatorial synthesis is shown in Figure 15.2. The technique involves three initial batches of resin beads to which are initially coupled, for example, a different amino acid. These batches are then combined, mixed and split again into three batches each batch now containing a mixture of beads containing different amino acids. A different amino acid is then coupled to each of these batches of beads, the beads mixed, split and the process repeated a third time. This simple... 

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