Spleen, transaminase activities

In mice intraperitoneally administered 15 mg/kg of usnic acid daily for 15 days, elevated levels of serum transaminase activity and extensive liver necrosis were observed. No signs of toxicity in other organs, such as the kidney or spleen, were detected. A similar pattern of toxicity was revealed in tumor-bearing mice (da Silva Santos et al. 2006 Ribeiro-Costa et al. 2004). 

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