Spiroalkyl analogs

To investigate the effect of changes at the C26 position of MFA on anthelmintic activity, several of C26-dialkyl and spiroalkyl analogs were prepared [47]. The analogs were synthesized in four steps starting with cathecol 66 [Fig. (19)], which was prepared from MFA in 80% yield by stirring in formic acid for 16 h. 

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