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Spiro pyrrolidine-2,3’-oxindoles libraries

A spiro[pyrrolidine-2,3 -oxindole] library <1998TL2235> has been synthesized via a three-component 1,3-dipolar cycloaddition in the solution phase. Isatins 432 were treated with L-proline or L-thiaproline and chalcone 433 in a MeOH-H20, CH3CN-H20, or dioxane-H20 solution. Spiropyrrolidines 49 (Scheme 96) were obtained as the sole products in good yield and high purity (Table 15). [Pg.693]

An Example Synthesis of a Spiro[Pyrrolidine-2,3 -Oxindole] Library... [Pg.358]

TABLE 8.1 Spiro [pyrrolidine-2,3-oxindole] Discrete Library L5 Chemistry Assessment and Monomer Rehearsai... [Pg.360]

See also in sourсe #XX -- [ Pg.358 , Pg.359 , Pg.435 ]



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2-Oxindole

Oxindol

Spiro oxindole

Spiro-oxindoles

Spiro-pyrrolidines

Spiro[pyrrolidin-3,3 -oxindoles

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