Spiro-isoquinoline derivative

Reductive JV(2)-cycloalkylation of 1,3,4,6,7,llfc-hexahydro-2H-pyra-zino[l,2-a]isoquinolin-4-one with 4-spiro derivatives of cyclohexanone in... 

Stevens rearrangement of methoiodides of 2,3,4,6,ll,lla-hexahydro-l//-pyrazino[l,2-h]isoquinolin-l-ones in the presence of 0.5 eq LAH gave T-methylindane-2-spiro-2 -piperazin-3 -ones (73CPB2661). When 10 eq LAH were applied, the oxo group of the spiro derivatives was also reduced [74GEP2356999,74JAP(K)74/72276]. 

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