Spheroides rubripes

It is well known that puffer generally contains TTX. TTX intoxication in humans most often results from ingestion of the liver of certain toxic species. Takahashi and Inoko (1889a,b) first attempted to study the chemical and physical properties of TTX partially purified from puffer. Later, TTX was successfully purified from the ovaries of puffer Spheroides rubripes. The structure of TTX was, however, approved in 1964 at the Fourth International Symposium on the Chemistry of Natural Products held in Japan, with the molecular formula of CnHnNsOg. Subsequently, the adopted term TTX attracted the attention of toxicologists, chemists, and pharmacologists, particularly for human intoxication. 

Tetra- odontidae Spheroides rubripes Spheroidine MP Yamakawa et al, 1923... 

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