Speed of searches

Data from computing-intensive prediction servers is precomputed, collected, and indexed (e.g., PSORT II [Nakai and Horton, 1999] or SMART [Letunic et al, 2004]). Harvester provides these data instantaneously and thus increases the speed of searches drastically compared to searching the respective databases manually one after the other. Pages older than 21 days are continuously updated. The quality of the collected information automatically increases with the quality of the crawled data servers, which themselves collect their information from several sub sources but quality-check them prior to publication (Apweiler et al, 2004 Diehn et al, 2003). 

An important aspect of biological transport is that nature makes extensive use of the reduction of dimensionality to speed up search and discovery (SD) (see also section C2.14.6.2). SD is enonnously enlranced upon moving from tliree to two or one dimensions, because the spatial extent to be explored is drastically reduced. Affinity follows kinetics in being enlranced upon moving from tliree dimensions to two dimensions 1791. 

Most mass spectrometers for analytical work have access to a large library of mass spectra of known compounds. These libraries are in a form that can be read immediately by a computer viz., the data corresponding to each spectrum have been compressed into digital form and stored permanently in memory. Each spectrum is stored as a list of m/z values for all peaks that are at least 5% of the height of the largest peak. To speed the search process, a much shorter version of the spectrum is normally examined (e.g., only one peak in every fourteen mass units). 

One of the obstacles in this aim is the lack of experimental thermodynamic data for activity coefficients in ionic liquids, which could be a basis for such solvent selection. In the past years several groups have started to measure such data however, there is a lack of data because the number of suitable anions and cations, and even more the number of ionic liquids, are rapidly increasing compared to the rate (or speed) of measurements. Reliable inter- and extrapolation schemes and group contribution methods are still missing. Thus the search for an appropriate ionic liquid for a certain task can, at present, only be made randomly or by systematic measurements. 

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