Speed congenics

Somlyo It takes about a year, at very best, doing the speed congeneic line. We have been burned with knockouts in the past. 

Somlyo The trouble is that to make a true congenic by conventional means takes two to three years. You can do a speed congenic in about eight months. But for those of us who like to look at force development it is a rather long time to wait. I have a mechanistic question. Has anyone looked at the leak from the SR There was an old debate as to whether PLB did something to the uptake mechanism is it direct or is it via creating a leak ... 

Wakeland E, Morel L, Achey K, Yui M, Longmate J Speed congenics a classic technique in the fast lane (relatively speaking). Immunol Today 18 472-477,1997... 

The Jackson Laboratory. Speed congenic development service. 2010. Retrieved from http //jaxservices.jax.org/speedcongenic.html. 

---