Spectroscopic Analysis of IVC-IVF

In H NMR spectra of IVC-IVE, the chemical shifts of aromatic protons appeared at 6.5-7.7 ppm generally. The protons of two methyl groups on the 5-position of 1,3,2-dioxaphosphinane were not chemical-shift equivalent and 

For IVF, there are two chiral centers in their molecule structure which caused diastereoisomer mixtures. In NMR spectra of IVF, the chemical shift and coupling split of protons were similar to those of IVE, but we could observe signals divided into two groups very clearly. The NMR spectra of IVC-19, IVE-7, and IVF-5 are shown in Figs. 5.9, 5.10, and 5.11. 

In NMR spectra of IVC-IVF, the chemical shifts of carbonyl carbon typically appeared at 165-168 ppm. The carbon signal corresponding to the P-CH-O appeared at 63-66 ppm as a doublet due to the coupling with phosphorus and the coupling constant Vp c was 160-170 Hz. The NMR spectrum of IVE-8 is shown in Fig. 5.12. 

In P NMR spectra of IVC-IVF, chemical shifts of the phosphoms appeared very regularly according to the type of R. IVC with substituted phenyl as R, their phosphorus signals appeared at 8-10 ppm. IVD with furyl as R, their phosphoms 

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