Spectrometer throughput

Direct feed of CO2 to a negative ion source was demonstrated in 1984 (Middleton, 1984), but subsequent attempts to use this gas in carbon dating (Bronk Ramsey and Hedges, 1997) and in biochemistry (Liberman et al., 2004) suffered from reduced spectrometer throughput or decreased precision, to the point that CO2 is seldom used in carbon spectrometers except for particular... 

A considerable amount of time is necessary to reach the point at which sample analyses can commence, and it is essential that the stability and reliability of the mass spectrometer be high to ensure maximum sample throughput during the limited time available between calibration checta. 

The mass spectrometer usually found on ICPMS instruments is a quadrupole mass spectrometer. This gives high throughput of ions and resolutions of 1 amu. Only a... 

In the infrared spectral range in general Fourier transform (FT) interferometers are used. In comparison with dispersive spectrometers FTIR enables higher optical throughput and the multiplex advantage at equivalent high spectral resolution. In... 

Yaccato K, Hagemeyer A, Lesik A, Volpe A, Weinberg WH. 2004. High throughput screening of low temperature SCR and SCD de-NOx catalysts in scanning mass spectrometer. Top Catal 30/31 127-132. 

Chromatography is typically at atmospheric pressure while source pressures in the mass spectrometer are in the range of 2 to 10 Torr for chemical and electron impact ionization, respectively. The interface must be capable of providing an adequate pressure drop between the two instruments and should also maximize the throughput of seuaple idiile maintaining a gas flow rate compatible with the source operating pressure. Further, the Interface should not introduce excessive dead volume at the column exit and should not degrade or modify the chemical constitution of the sample. 

In-situ Fourier transform infrared spectroscopy. The final technique in this section concerns the FTIR approach which is based quite simply on the far greater throughput and speed of an FTIR spectrometer compared to a dispersive instrument. In situ FTIR has several acronyms depending on the exact method used. In general, as in the EMIRS technique, the FTIR-... 

Another MS-based approach used in high-throughput bioanalysis utilizes a mass spectrometer equipped with several API spray probes. Each of the analytical columns in parallel is connected to a separate spray probe and each spray is sampled in rapid successions for data acquisition by the MS. A separate data hie for each spray is recorded. Several samples can be analyzed simultaneously on parallel columns5 6 in the course of a single chromatographic run. 

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