Spectra-structure correlations steroids

The wide variation in structure, ranging from complex steroids to the inert monatomic gas xenon, led to several theories of anesthetic action. The mechanism by which inhalation anesthetics manifest their effect is not exactly known. Since they do not belong to one chemical class of compounds, the correlations between structure and activity are also not known. Inhalation anesthetics are nonspecific and therefore there are not specific antagonists. Interaction of inhalation anesthetics with cellular structures can only be described as van der Waals interactions. There are a number of hypotheses that have been advanced to explain the action of inhalation anesthetics however, none of them can adequately describe the entire spectrum of effects caused by inhalation anesthetics. 

Fig. 7 Aliphatic region of a NOESY spectrum of dutasteride in DMSO-d6- Correlations show through space interactions between neighboring nuclei and are used to make relative stereochemical assignments for proton resonances. Correlations between the His methyl group and nearby protons on the same side of the steroid ring system are highlighted. (See Fig. 10 for structure and numbering scheme.)...

H Spectra.—The total analysis of the 1H n.m.r. spectrum of 11 p-hydroxypro-gesterone, reported briefly last year,42 has now been described in full.43 This is a further illustration of the value of computer-controlled use of a 400 MHz spectrometer to obtain two-dimensional J spectra, and n.O.e. difference and decoupling difference spectra, which provided all the XH chemical shifts and virtually all geminal and vicinal coupling constants. Comparisons with the previously reported findings42 for 1-dehydrotestosterone acetate represent the first step in a correlation of detailed n.m.r. and structural parameters which promises to have widespread application in future studies on steroidal and terpenoid compounds. 220 MHz spectra permit quantitative estimation of C-24 epimeric mixtures of 24-alkyl sterols.44... 

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