Spectra 17/?-estradiol

MW 272 Da), the control compound in the study (Fig. 2.13), and WY234 (fCa 5 pM, MW 253 Da Fig. 2.14). 17j8-Estradiol is a relatively less polar material and was studied in the negative atmospheric pressure chemical ionization (APCI) mode since it produced a weak APCI spectrum in the positive mode and no spec-... 

Fig. 8.19. Coordination ion spray mass spectrum of estradiol extracted from the reversed-phase CEC—CIS-MS separation of estrogenic compounds. Column, 250 x 0.1 mm i.d. packed with 3 pm GROM-SIL ODS-O AB eluent, 4 mmol/1 ammonium acetate, pH 9.0, 50% acetonitrile applied pressure, 8 MPa applied voltage, 15 kV detection, ESI-MS, 0.85 s/spectrum sheath liquid, 100 pg/ml aqueous silver nitrate, 3 pl/min mass spectrum extracted from a reconstructed ion chromatogram of the separation of estriol, estradiol, equiline, and estrone. (Reproduced from ref. [104] with permission of Wiley-VCh).

There also exist a class of ligands referred to as SERMs (selective estrogen receptor modulators) that display tissue-selective pharmacology [13]. Raloxifene and tamoxifen are two clinically used SERMs for which structures are available. Crystal structures of the estrogen receptor bound to different ligands (estradiol, tamoxifen, or raloxifene) reveal that ligands of different sizes and shapes induce a spectrum of receptor conformational states. These states can be interpreted by the cellular complexion of co-regulators and the environment of the local promoter of... 

The Oppenauer oxidation of (426) led to the methyl ether of 6-azaequile-nin (430) the structure of which had been confirmed by its mass spectrum [537-539]. By an analogous series of reactions, the 6-oxa derivatives of estrone and estradiol have been obtained from the chromanone (431) [536, 540-543].t... 

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