Species Differences among LBD Sequences

GLIEEQRKMIRELMDAQMKTFDTTFSHFKNFRLFGVLSSGCELPESLQAPSREEAAKWSQVRKDLCS---GL1 SEQRMMXFiBLMDAQMKT FDTT PSH FKMFRLFGVLSSGCEMPB S LQAF SRB AAKKNQVRKDLWS-- - 

IEDQI EEDQI IEDQI EEDQI EEDQl AEDDQI EEDQI EEDQI 4BDQX EDQI FsJEDQl EDDOI 

FAT PLMQELFGI FAT PLMQRLFGI FAT PLMRBLFSTTDD FAT PLMQELFSSTPG FAT PLMQRLF8 STDG 

FIGURE 5.3 Sequence alignment of PXR and CAR from different species. Secondary structure elements are noted with H representing helices and S for strands. The color code for amino acid residues is as follows red for acidic residues blue, basic residues green, hydrophobic residues and grayish blue, polar residues. Three strands were observed in the CAR LBD (labeled as SI, S2, and S3) and five strands in the PXR LBD (labeled from SI to S5). See color insert. 

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