Special Population Subjects with Renal Impairment

Geometric mean (arithmetic mean) (N = 32) Point estimate/(95% Cl)1 [Pg.689]

3Point estimates and 95% confidence intervals for therespective median differences from non-parametric data analysis. [Pg.689]

The total systemic insulin glulisine availability as presented by [AUC(o-ciamp end)] was similar for the two modes of administration of insulin glulisine and NPH insulin, mixed in a syringe immediately before injection (treatment B), and the separate simultaneously injections (treatment A). [Pg.689]

The maximum insulin glulisine concentration Cmax was somewhat attenuated, being 27% less, when insulin glulisine was premixed with NPH insulin as compared to the separate simultaneous administration. Nevertheless, the time to Cmax did not differ between the two treatments with Tmax values of 47 and 50 minutes (min). [Pg.689]

The MRT of insulin glulisine was somewhat longer when insulin glulisine was premixed with NPH insulin (118 min) compared to their simultaneous administration (92 min), corresponding to an average increase of 27%. [Pg.689]

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