Sorting of Bacterial Proteins

In recent years, a surprise in the study of signal peptides has been that signal peptides can be recognized by different factors, and the differences of their sequence features determine the preferences to these factors (Zheng and Gierasch, 1996 Siegel, 1995). 

Similar to SRP-dependent, but length and/or hydrophobicity of h-region is smaller also used at endoplasmic reticulum (ER) 

Longer in length (26-58aa) twin-arginine motif in n-region also Sec-avoidance lysine in c-region not found at ER but found at chloroplasts 

Type II signal sequence used for lipoproteins LA(G/A) C motif for cleavage in c-region 

Forms opposite NexoCcyt orientation few or no charges in n-region longer h-region is favored than in type II anchor 

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