Somogyi phenomenon

A rebound hyperglycaemia, caused by counter-regulatory hormones provoked by insulin-induced hypoglycaemia, is called the Somogyi phenomenon (Gerich, 1988). Attvall etal. (1987) have shown that prolonged... 

It is important to prevent nocturnal hypoglycaemia, not only to protect brain function, but also to prevent insulin resistance. This may easily result in exaggerated hyperglycaemia and initiate the vicious circle -hypoglycaemia, hyperglycaemia, increase in insulin dose and risk of subsequent hypoglycaemia (Bolli and Perriello, 1990). The mechanism, frequency and even the existence of the Somogyi phenomenon, however, are all still controversial. 

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