Some Requirements for a Successful PTC Reaction

The phase transfer catalytic process involves at least three important steps (1) the reactant transfer step, in which the reactant anion is transferred from the aqueous or solid phase into the organic phase (2) the reaction step, in which the 

Since Murphy s laws mle in organic synthesis as well as in the rest of the world, it is important to take into consideration as much previous knowledge as possible when making a first attempt at using new or unfamiliar technology such as PTC. With PTC, it is possible to minimize disappointments by considering a few essential points  

PTC reactions can be tricky, so patience and perseverance are important ingredients in the stew. It is important not to expect an immediate boom (speaking figuratively and hopefully, not literally). Optimizing trials will almost certainly be needed to follow up preliminary reactions. 

In both 11-PTC and sI-PTC inert, polar, nonprotic solvents are recommended. In addition, in 11-PTC the solvent should not be water-miscible. 

Work with relatively concentrated solutions, using one of the reactants as a solvent if practical. 

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