Some General Methods for Phosphate Ester Formation

SOME GENERAL METHODS FOR PHOSPHATE ESTER FORMATION [Pg.939]

Phosphoric acids may be esterified using an alcohol and an activating agent [Pg.939]

Nucleophilic (Sn2) reactions for the formation of henzyl, allyl, and certain alkyl phosphates [e.g., Mc4N (R0)2P(0)0 and an alkyl halide in refluxing [Pg.940]

Reaction of a phosphoric acid with a diazoalkane (CH2N2, ArCHN2, (A/-oxido-a-pyridyl)CHN2, Ar2CN2). [Pg.940]

Primary alcohols may be phosphorylated by use of the Mitsunobu reaction (PhsP, DEAD, HBF4, Pyr). Of several salts examined, the potassium salt of the phosphate was the best. [Pg.940]

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