Soman human exposure studies

Agent GD (Soman). RfDg = 4 x 10 mg kg d" A LOAEL was identified in a 90-d oral study in rats. A total uncertainty factor of 3000 was applied to account for protection of sensitive subpopulations (10), animal-to-human extrapolation (10), LOAEL-to-NOAEL extrapolation (3), extrapolation from a subchronic to chronic exposure (3), and incomplete data base (3). An uncertainty factor of 3 rather than the default value of 10 was used to extrapolate from a subchronic to chronic exposure because of the unlikelihood that the LOAEL would have been substantially lower if the exposure had continued for a longer period of time. A LOAEL-to-NOAEL uncertainty factor of 3 was used because... 

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