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Solvent strength versus composition

The present model predicts how solvent selectivity will vary with mobile-phase composition, and this allows the selection of extreme solvents for maximum differences in selectivity. This information plus the ability to calculate solvent strength versus composition of the mobile phase then allows development of a general strategy for optimizing retention of any sample, so as to maximize resolution. This four-solvent approach can be further refined by use of computer-assisted procedures, such as the overlapping-resolution-mapping technique. [Pg.216]

Abbott et al. [4] devised a method designed to predict the retention times in gradient elution under the assumption that the retention factor as determined under isocratic conditions is a log-linear function of solvent composition according to Eq. (5), where k is the retention factor obtained in water, ipo refers to the volume fraction of the organic component, and S refers to the solvent strength for which the values can be obtained as the negative slope of plots of log k versus volume fraction ... [Pg.763]

See other pages where Solvent strength versus composition is mentioned: [Pg.209]    [Pg.209]    [Pg.51]    [Pg.126]    [Pg.139]    [Pg.196]    [Pg.382]    [Pg.243]    [Pg.316]    [Pg.148]    [Pg.54]    [Pg.874]    [Pg.549]    [Pg.193]    [Pg.43]   
See also in sourсe #XX -- [ Pg.161 , Pg.182 , Pg.183 , Pg.184 , Pg.185 , Pg.186 , Pg.187 , Pg.188 , Pg.189 , Pg.190 , Pg.191 , Pg.192 ]



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