Solvent-Free N-S Bond Formation

Type of reaction S-N bond formation Reaction condition solid-state 

Solid p-toluenesulfonylchloride 1 (1.00 mmol) in an evacuated 100-mL flask was exposed to the amine gas (0.5 bar). After 2 h the excess gas was condensed to a trap at 77 K and the quantitatively obtained 2 washed with water and dried in a good vacuum. 

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