Solution- Versus Solid-Phase Synthetic Libraries Which Ones to Use

1 SOLUTION- VERSUS SOLID-PHASE SYNTHETIC LIBRARIES WHICH ONES TO USE  

Synthetic strategies based on solution-phase (Fig. 8.1, left) or SP reactions (Fig. 8.1, right) can be compared by considering the synthesis of single-target compounds. To all intents and purposes, there is no apparent similarity between the two techniques  

The comparison is different when dealing with combinatorial libraries  

Having said this, the synthesis of solution-phase libraries is possible, and indeed is more appropriate, than the corresponding SP chemistry under certain circumstances. The value of such libraries is discussed in the following sections, but it is appropriate to stress the concept of complementarity, rather than mutual exclusivity of the solution and SP library formats. The goal for a combinatorial chemist is always to select the best library format according to the needs of the project without exclusion of individual options due to personal preference. 

2 Pool Libraries Solution Versus Solid Phase 

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