Solution-Phase Derivatization to Facilitate Polymer-Assisted Sequestration

SOLUTION-PHASE DERIVATIZATION TO FACILITATE POLYMER-ASSISTED SEQUESTRATION 

Direct sequestration of a reactant by an insoluble resin is impractical if the kinetics is sluggish and impossible if the solution-phase reactant does not contain a functionality to enable direct sequestration. These limitations led several research groups to use bifunctional solution-phase linking reagents, also referred to as sequestration-enabling-reagents. 33 

Solution-phase syntheses employing linking reagents provide an alternative to solid-phase organic synthesis when poor conversions and incomplete reactions yield deletion intermediates upon release from resin. Applications are highlighted in various multistep syntheses covered at the end of this chapter. 

Poorly reactive (poorly sequestrable) byproducts are more frequently encountered than poorly sequestrable reactants. A few reports have appeared describing the use of soluble bifunctional linking reagents to chemically tag 

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