Soluble supports glycopeptide

Soluble polyethylene glycol (PEG) as polymer support was also successfully investigated. Precipitation after each reaction step in order to remove excesses of reagents and soluble byproducts seemed to work well. Another topic of great interest is direct glycosylation of solid support connected peptides in order to arrive finally at glycopeptides. (9-Glycosyl trichloroacetimidates also proved successful in this endeavor. 

Figure 5 Chemoenzymatic synthesis of glycopeptide using a combination of solid-phase and water-soluble polymer supports.

Fumoto M, Hinou H, Matsushita T, Kurogochi M, Ohta T, Ito T, Yamada K, Takimoto A, Kondo H, Inazu T, Nishimura S. Molecular transporter between polymer platforms highly efficient chemoenzymatic glycopeptide synthesis by the combined use of solid-phase and water-soluble polymer supports. Angew. Chem. Int. Ed. Engl. 2005 44 2534-2537. 

Nishimura and co-workers have developed the catch-and-release strategy between solid-phase and water-soluble polymer supports, the so called pol)uner blotting method , which allows for the rapid and efficient synthesis of glycopeptides [76]. The method involves (i) conven-... 

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