Solubilization in Aqueous Media

FIGURE 4-1 Plot of amount of material solubilized as a function of concentration of the surfactant in the bulk phase. 

---

Yalkaowsky SH. Solubility and Solubilization in Aqueous Media. Washington D.C. American Chemical Society, 1999. 

Yalkowsky, S. H. 1999Solubility and solubilization in aqueous media. New York Oxford University Press. Young, T. J., S. Mawson, K. P. Johnston, I. B. Henriksen, G. W. Pace, and A. K. Mishra. 2000. Rapid expansion from supercritical to aqueous solution to produce submicron suspensions of water-insoluble drugs. Biotechnol. Prog.16 402-407. 

Yalkowsky SH. 1999. Solubility and solubilization in aqueous media. Washington, DC American Chemical Society/New York Oxford University Press. 

According to Eq. (32), the factors that determine the degree of solubilization of the solute are the complexation constant and the solubilities of the solute, the ligand, and the complex. As a result, the most useful ligands for solubilization in aqueous media are highly water soluble, and produce soluble complexes. 

Hydrogels Chemical or enzymatic hydrolysis, solubilization in aqueous media Kamath and Park, 1993... 

Water-soluble pillar[6]arenes can be prepared using the same method as the synthesis of water-soluble pillar[5]arenes. The introduction of water-soluble substituents, such as cationic, anionic and nonionic moieties, allows pillar[6]arenes to solubilize in aqueous media. The first water-soluble pillar[6]arene was synthesized by Huang and co-workers, by introducing 12 carbojylate moieties (Figure 5.31, H5.36). H5.36 could capture paraquat (Table 5.9, run 145, G5.117) in water with a high association constant [ T= (1.02 0.10) x 10 M ], which is much higher than that of the anionic water-soluble pillar[5]arene H5.11 [Table 5.4, run 63, K= (8.20 1.70)xl0 M... 

---