Solubility protein-based biological

In particular, in this chapter we examine a number of protein-based biological systems that can present excesses of insolubility or solubility. Some of these, for example, muscle contraction and hemoglobin transport of oxygen. 

As is argued in Chapter 8, small, often reversible, energy excursions back and forth across the boundary between associated (water-insoluble) and dissociated (water-soluble) oil-like domains (clusters of oil-like groups) drive the protein-based machines of biology. Biology often achieves mobility by many linear motors comprised of protein, such... 

The existence of soluble protein-polyelectrolyte complexes makes polyelectrolytes potentially important enzyme carriers, in which the enzyme activity could be controlled. For example, the tryptic digestion of hemoglobin with PAA as a carrier was studied by Morawetz [56] in 1955. The trypsin activity was varied by adjusting pH and polymer concentration. It was found that the carrier could even activate the enzyme at low pH, as shown by Fig. 15.22. As shown in Fig. 15.23, the complex of trypsin with KPVS was found to retain activity in a wide pH range by Kokufuta [57]. Based on the study of trypsin-carboxymethyl-cellulose complexes, Larionova et al. [58] concluded that some protein-polyelectrolyte complexes can provide extra thermal stability at the preservation of high biological activity. 

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