Solid tetrahydroquinoline based tricyclic

Fig. 17.10 Modular solution and solid phase approaches to obtain tetrahydroquinoline based tricyclic compounds containing different unsaturated lactam rings and macrocyclic rings, (a) (i) 20% piperidine, CH2CI2 (ii) Et3N, ac loyl chloride, —10°C, CH2CI2 (iii) ...

Fig. 17.12 In situ bridged aza Michael approach in solution and on solid phase to obtain tetrahydroquinoline-based tricyclic compounds, (a) (i) acetic acid/THF/H20, RT (ii) TESOTf, pyridine, CH2CI2, -40°C (iii) Pd(PPh3)4, morpholine, CH2CI2, RT (c) Et3N, benzoyl chloride or cinnamoyl chloride, CH2CI2, O C to RT.

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