Solid-phase multi-step

PA FT-IR has been successfully used by Gossehn et al. [182] for monitoring a solid-phase multi-step synthesis. However the use of PA FT-IR is not yet widespread, even though it is nondestructive and allows surface analysis. This could be caused by the high cost of the instrumentation coupled with larger sample requirements and sHghtly longer acquisition times. 

Carbo-2-(p-diphenyl)isopropoxy derivatives. N-2-(p-Diphenyl)isopropyloxycarbo-nylleucine stirred 1.5 hrs. at room temp, with acetic acid-formic acid-water (7 1 2) leucine. Y 94%. - Of a number of N-aralkoxycarbonyl protective groups tested 2-(p-diphenyl)isopropyloxycarbonyl was the most suitable for peptide syntheses (Helv. 51y 614). Selective and preferential removal in the presence of other acid-labile protective groups, especially those derived from rerr-butanol, also application in solid-phase multi-step syntheses, s. P. Sieber and B. Iselin, Helv. 51 y 622, 614 (1968). 

Merrifield syntheses (s. a. Solid-phase multi-step syntheses)... 

Hydrogen bromide acetic acid Solid phase multi-step syntheses Peptides... 

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