Solid-phase linkers, radical cleavage

The high purity (>95%) of the released product from resin 14 prompted us to investigate the potential of radical release as a traceless linker concept. To our knowledge, thermolytic radical fragmentation of covalent bonds is a mechanism of bond dissociation that has not been exploited so far for linker chemistry and for solid-phase transformations. Cleavage yields, determined by releasing nonvolatile products, were found to be higher than 90%. 

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