Solid-phase-bound ligand libraries

Jackson et al. furthermore prepared the solid-phase-bound ligand libraries 23 shown in Scheme 9 (27). The ligands consist of a solid-phase-bound dipeptide which is capped by a salicylic aldehyde. The screening of a number of... 

There is one more report on the synthesis of a library of phosphorus ligands on solid phase. Waldmann et al. prepared a library of phosphoramidites on beads (Fig. 36.5), but these were only applied in enantioselective C-C-bond formation. In fact, as two ligands need to be bound to the catalyst, the use of an immobilized monodentate ligands should most likely be avoided unless the proximity between the ligands is sufficiently close. In addition, crosslinking by the metal may have a negative impact on the permeability of the polymer for the substrate. 

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