Sodium periodate cross-linkers

The carbonyl-reactive functional group on these cross-linkers is a hydrazide group that can form hydrazone bonds with aldehyde residues. To utilize this functional group with carbohydrate-containing molecules, the sugars first must be mildly oxidized to contain aldehyde groups by treatment with sodium periodate. Oxidation with this compound will cleave adjacent carbon—carbon bonds that possess hydroxyl groups, as are abundant in polysaccharide molecules (Chapter 1, Sections 2 and 4.4). 

Figure 195 Cross-linkers containing a diol group in their cross-bridge design may be cleaved by oxidation with sodium periodate.

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