Sodium nitrite - Acetic acid

The first 1,2,3-thiadiazole synthesized, 1,2,3-benzothiadiazole, was prepared by diazotiz-ation of o-aminothiophenol with nitrous acid (equation 31) (B-61MI42400), and recently sodium nitrite-acetic acid has been substituted for nitrous acid (B-79MI42400),. Another modification, thermal decomposition of diazonium acetate (34), affords benzothiadiazole in good yield in contrast to the variable yields usually experienced in the diazotization of o-aminothiophenols (equation 32) (78SST(5)43l). Benzothiadiazoles are also available directly from aromatic amines (equation 33) (70JCS(C)2250). Sulfur monochloride reacts with the amine to form a benzothiazothiolium salt which reacts with nitrous acid to yield a chlorinated 1,2,3-benzothiadiazole (35). This process, depending on the aromatic ring substitution, may afford a number of products, and yields are variable. [Pg.460]

Hydrogen peroxide. Oxygen. cw-HYDROXYLATION Sodium nitrite-Acetic acid. [Pg.781]

Sulphated disaccharides from the sodium nitrite-acetic acid deamination of porcine and whale heparins have been isolated and characterized and the products compared. ... [Pg.645]

Arylsulfonylindazoles, novel S-HTe receptor antagonists, have been synthesized via the VNS reactions of para-substituted nitrobenzenes with carbanion of chloromethyl aryl sulfones followed by hydrogenation of the nitro group (Scheme 102). Further reaction of ortAo-aminobenzyl sulfones with sodium nitrite-acetic acid gave the desired 5-substituted indazoles of potential biological activity [237, 238]. [Pg.98]

Sodium nitrite acetic acid Azidoformic acid esters... [Pg.379]

Sodium nitrite acetic acid Partial c/ -hydroxylation of carbon-carbon double bonds... [Pg.51]

Sodium nitrite acetic acid Pyrimido[5,4-el-a -triazine-5,7(6H,lH)-diones... [Pg.100]

Sodium nitrite/acetic acid NaN02/MeC00H... [Pg.378]

Sodium nitrite acetic acid N-Condensed tetrazoles... [Pg.357]

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