Snail ACh-binding protein

The most important residues in neighbor, ing subunits that influence ACh binding art W57 of the 5 subunit and the homologous W5 of the y subunit (6, 29). The "minus" side o1 the AChBP interface, shown in Fig. 11,6b would be the y/e or the 8 subunit in the receptor, but in the AChBP it is another identica subunit. The residues shown to be in contaci with the ligand, labeled in Fig. 11,6b, mostlj have no obvious analog in the ACh receptor The one important exception is W53, which corresponds to the tryptophan residues men. tioned above. Consequently, the snail protein... 

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