SmithKline Beecham workers

Another method is to use poly-L-amino acids as catalysts in alkaline media (Julia-Colanna epoxidation) for the asymmetric epoxidation of chalcones and other electron-poor olefins with H202 [287]. SmithKline Beecham workers used this method (see Fig. 4.105) as a key step in the synthesis of a leukotriene antagonist, although it required 20 equivalents of H202 and 12 equivalents of NaOH, based on substrate [288]. The mechanism probably involves the asym-... 

Workers at SmithKline Beecham extended the synthetic access to interesting mono- and di-substituted oxazoles through an improved procedure for aryl-substituted... 

Workers at SmithKline Beecham reported the stereoselective synthesis of inhibitors of... 

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