Small Molecules or Ions of Biological Interest

In the foregoing section the halide binding sites were tacitly assumed to be present on a protein or some other macromolecule. This assumption is by no means necessary - the halide quadrupole relaxation technique has been applied quite successfully to study halide ion binding also to small molecules of biological importance. 

In two papers [294 419] Happe and Ward have reported investiga- 

Chapter 5). Addition of adenosine diphosphate (ADP) to the Zn containing solutions caused the linebroadening to increase markedly. 

Cl line width. The chemical exchange of Cl between free and com-plexed sites was assumed to be too fast to contribute to the observed 

2+ 2+ correlation time of the Zn -ADP-halide complex than of the Zn -halide 

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