Small molecular drug

MALDI-TOF-IMS allows for the analysis of large numbers of compounds ranging from small molecular drug and its metabolite molecules (m/z< 1,000) [73, 74] to large proteins with a molecular weight of 104 Da [75],... 

Applications to Small Molecular Drug Discovery and Development... 

Anesthetized rats are used for testing the side effect potential of a candidate compound on intermediary metabolism in liver, muscle and adipose tissue with subsequent effects on metabolic blood parameters (e.g. glucose, lactate, free fatty acids, triglycerides) and insulin. The use of anesthetized rats represents more a principal assessment of the pharmacological side effect potential since the candidate compound must be administered intravenously or intraperitoneally (enteral/intestinal administration should be avoided due to the anesthesia-induced decrease in intestinal motility with subsequent impairment of enteral absorption), compared to the study in conscious rats in which the candidate compound can be studied after oral administration, which in most cases represents the clinical route of administration for small molecular drugs. 

Conscious rats are used for testing the side effect potential of a candidate compound on intermediary metabolism in liver, muscle and adipose tissue with subsequent effects on metabolic blood parameters (e.g. glucose, lactate, free fatty acids, triglycerides) and insulin after oral administration, which represents in most cases the clinical route of administration for small molecular drugs. 

Tsuji A (2005) Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems. NeuroRx 2 54—62. 

S. Wang, et al. (2010) Towards sustained delivery of small molecular drugs using hydroxyapatite microspheres as the vehicle. Advanced Powder Technology 21 268-272. 

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