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Small CXCR3 antagonists

CXCR3 Small Molecule Antagonists. To date, there are very few reports on small molecule antagonists for this receptor. The 4-OXO-2,4-dihydro quinazoline (68) is re-... [Pg.166]

Hayes, M.E., Wallace, G.A., Grongsaard, P., BischofF, A., George, D.M., Miao, W., McPherson, M.J., Stoffel, R.H. et al. (2008) Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3. Bioorganic S. Medicinal Chemistry Letters, 18, 1573-1576. [Pg.321]

To date, no small-molecule inhibitors of CXCR3 have been published, although murine CXCR3 can be blocked by the CCR5 antagonist TAK-779 (Gao et al., 2003). Despite this absence of published data, T-487 has entered Phase n clinical trial by ChemoCentryx for the treatment of psoriasis. The drug is orally available and was well tolerated in Phase I trials, according to company reports. [Pg.337]

See other pages where Small CXCR3 antagonists is mentioned: [Pg.135]    [Pg.304]    [Pg.310]    [Pg.313]    [Pg.135]    [Pg.304]    [Pg.310]    [Pg.313]    [Pg.130]    [Pg.75]    [Pg.487]    [Pg.504]    [Pg.301]    [Pg.302]    [Pg.303]    [Pg.303]    [Pg.307]    [Pg.312]    [Pg.315]    [Pg.315]    [Pg.320]    [Pg.236]    [Pg.332]    [Pg.343]    [Pg.346]    [Pg.224]    [Pg.339]    [Pg.79]    [Pg.83]    [Pg.88]    [Pg.221]   
See also in sourсe #XX -- [ Pg.135 , Pg.304 , Pg.310 , Pg.313 ]



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CXCR3 antagonists

Patents on Small CXCR3 Antagonists

Publications on Small CXCR3 Antagonists

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