Sliding filament cross-bridge model

The Sliding Filament Cross-Bridge Model Is the Foundation on Which Current Thinking About Muscle Contraction Is Built... 

Figure 14.12 The swinging cross-bridge model of muscle contraction driven by ATP hydrolysis, (a) A myosin cross-bridge (green) binds tightly in a 45 conformation to actin (red), (b) The myosin cross-bridge is released from the actin and undergoes a conformational change to a 90 conformation (c), which then rebinds to actin (d). The myosin cross-bridge then reverts back to its 45° conformation (a), causing the actin and myosin filaments to slide past each other. This whole cycle is then repeated.

Figure 14.17 A sequence of events combining the swinging cross-bridge model of actin and myosin filament sliding with structural data of myosin with and without bound nucleotides.

Figure 2.15. A primitive swinging cross-bridge/ sliding filament model of muscle contraction is introduced for the purpose of providing a conceptual bridge from the simple oil-like dissociation/assoda-tion for the opening/closing of a clam-shaped globular protein toward the more complex structural aspects of muscle contraction. Major limitations in...

Tirosh, R Liron, N. Oplatka, A. A hydrodynamic mechanism for muscular contraction. In Cross-Bridge Mechanism in Muscle Contraction, Proceedings of the International Symposium on the Current Problems of Sliding Filament Model and Muscle Mechanics, Tokyo, Japan, 1978. University of Tokyo Press Tokyo, 1979 pp. 593-609. 

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