Skeletal muscles hypoxic response

Hypoxia decreases resistance to blood flow in many vascular beds. This could be a compensatory mechanism to increase blood flow to the hypoxic region. In the coronary, cerebral, renal, and skeletal muscle circulations this hypoxic vasodilation is attenuated by glibenclamide, suggesting a role for K xp channels in the response (von Beckerath et al., 1991 Daut et al.,... 

Halothane (Fluothane) Mechanism unclear. Induces rapid, comfortable anesthesia and skeletal muscle relaxation. i cardiac output, mild T of systemic vascular resistance, typically no effect on heart rate, 1 right atrial pressure, moderate depression of myocardial function, most likely to sensitize myocardium to catecholamines and i baroreceptor reflex. t ventilation control (T tidal volume, >1 rate of breathing, i response to CCfe and hypoxia), bronchodilation (mostpotent), No effect on hypoxic pulmonary vasoconstrictor response, depression of ciliary function and mucous clearance. 

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