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Site-directed ligand design

R. A. Lewis, Biochem. Soc. Trans., 19,883 (1991). Rational Methods for Site-Directed Drug Design Novel Approaches for the Discovery of Potential Ligands. [Pg.115]

Gehlhaar, D. K., Bouzida, D., and Rejto, P. A. (1999) Reduced dimensionality in ligand-protein structure prediction covalent inhibitors of serine proteases and design of site-directed combinatorial libraries. ACS Symposium Series 719, 292-311. [Pg.376]

Oseltamivir (1) is a prodrug of GS-4071 (7, Fig. 7.2). It is also a potent competitive inhibitor of viral neuraminidase glycoprotein for both influenza A and B types. Similar to zanamivir (2), oseltamivir (1) is also the fmit of SBDD in the sense that the protein structure directed the design of the ligand (sialic acid) and the protein-bound ligand conformation is close to the designed stmcture. In particular, the neuraminidase active site contains several... [Pg.97]

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