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SiRNAs molecules silencing effect

Not all siRNAs are created equal and a major effort has been made to determine the best siRNAs to knockdown a gene of interest. Understanding the next step in the RNAi pathway downstream of Dicer has proven very helpful in this respect. The siRNA molecules generated by Dicer become incorporated with the RNA-induced silencing complex (RISC) that uses the short RNA as a template to target an mRNA species for cleavage and eventual degradation (35). However, each RISC complex contains only one strand of ssRNA from the siRNA duplex (36) therefore, to produce an effective knockdown, it must incorporate... [Pg.166]

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See also in sourсe #XX -- [ Pg.3150 ]



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Molecules effects

SiRNA

SiRNAs

SiRNAs molecules

Silence

Silencers

Silencing

Silencing effects

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