Single Scan Multidimensional Spectroscopy

A different type of a single-scan experiment was used by Loening et al. ° for the measurement of Ti relaxation. In the proposed version the relaxation is encoded in individual slices of the sample which are then sequentially selected for observation with a slice-selective spin-echo sequence in the presence of the gradient. No gradient is used during the acquisition and the chemical shift information is retrieved by the Fourier transformation from an ordinary FID. Each acquisition has to fit between the Ti increment points. Alternatively, a weak gradient is used in the acquisition time to decode the Ti information. 

Srot and Frydman noted that the line-shape in the indirect dimension of a single-scan experiment depends on the solute distribution throughout the sample. The uniform distribution leads to a Sine function and the deviation from that can be used to evaluate the deviations of the distribution from uniform. The signals in the proposed 2D single-scan experiments are resolved in two spectral dimensions and include a TOCSY mixing sequence. 

The discrete nature of ti incrementation during the spatial encoding of the single-scan experiments leads to the appearance of ghost peaks in the indirect dimension, a periodic refocusing artefacts around the central peak. These arte- 

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