Single Particle ICP-MS Studies

FIGURE 20.5 Principles of characterizing nanoparticles using sp-ICP-MS analysis (see text for explanation of numbers). (Courtesy of the Colorado School of Mines.) 

FIGURE 20.6 Time-resolved pulses of NIST SRM (RM 8013), 60-nm nanoparticle gold standard. 

By using a series of nanoparticle standard reference materials (SRMs) and applying cumulative distribution function to this histogram, we can plot the cumulative distribution versus signal intensity (counts). The math is beyond the scope of this chapter, but by using these data, a calibration of median intensity can then be plotted 

FIGURE 20.7 Average intensity (n = 3) distribntion for NIST RM 8013 SRM (60-nm gold nanoparticles) with a measnred median intensity of 42 connts. 

FIGURE 20.8 A plot of 3 NIST gold nanoparticle SRMs (10, 30 60 nm gold particles), against the median intensity of their respective ICP-MS counts. 

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Data Quality Objectives for Single-Particle ICP-MS Studies... 

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