Single nucleotide polymorphism liquid chromatography

Song, R. et al. Analysis of single nucleotide polymorphism sites in exon 4 of the p53 gene using high-performance liquid chromatography/electrospray ionization/tandem mass spectrometry. Eur. J. Mass Spectrom. 2006, 12, 205-211. [Pg.191]

Key Words Denaturing high-performance liquid chromatography (DHPLC) genotyping mutation detection single-nucleotide polymorphism (SNP) single-base extension (SEE). [Pg.73]

In Chap. 10, McFarlane et al. utilize liquid chromatography (LC)-MS to generate intact protein expression profiles as a snapshot of expressed proteins in a wide range of bacterial samples. Subsequent top-down proteomic analysis by LC-tandem MS allows identification of expressed serovar-specific proteins, resulting from nonsyn-onymous single-nucleotide polymorphisms (SNPs). Closely related, unsequenced or bacterial strains with newly acquired SNPs and plasmid proteins can be successfully differentiated by this multiplexed approach. [Pg.5]