Single-channel approximation

By neglecting the off-diagonal coupling potentials in the coupled equations [Eq. (95)], we obtain a single-channel approximation... 

S5-S6 loop region in DRKl by the one of NGK2 confers to the recombinant channel the single-channel conductance and TEA sensitivity of NGK2 [47], Thus, a region of approximately twenty amino acids in the primary sequence of K channels controls essential properties of the K" channel pore [48]. 

The profile of the tracer recovery curves (breakthrough curves) is best approximated and simplified using a single channel communication between the injection and production wells both for 1,6 and 2,6 NDS tracers. 

Catalytic combustion in a monolith channel provides an illustration of boundary-layer flow in a channel [322], Figure 17.18 shows a typical monolith structure and the particular single-channel geometry used in this example. Since every channel within the monolith structure behaves essentially alike, only one channel needs to be analyzed. Also a cylindrical channel is used to approximate the actual shape of the channels. 

To a first approximation, ion channel opening is an all-or-none stochastic event and the effect of a stimulus, chemical or physical, is to alter the probability of channel opening. Patch clamp techniques make it possible to observe the opening or closing of single channels and thus to measure single molecular events. This ability, coupled with recent structural information on the channel, makes possible to a first approximation a molecular description of ion channel function. 

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