Simultaneous, fatigue resistance

Stainless steels are subject to fatigue failure under dry conditions as are all metallic materials, having distinct fatigue limits where level is dependent on steel type and heat treatment. The limits can be depressed by the simultaneous action of a corrodent, the degree depending upon the nature of the corrodent. Under severe conditions the limit can be displaced to very low values and it is customary to describe resistance by an endurance limit, that is the cyclic stress to give rupture at a specific number of cycles when in contact with a specific corrodent. Some comparative data are in Table 3.25. 

Lamivudine is the best-tolerated NRTI. Its most common adverse effects include headache, malaise, fatigue, and insomnia. Pancreatitis is rare. Gastrointestinal complaints are common with lamivudine-zidovudine therapy but are probably mainly due to the zidovudine component. Lamivudine resistance sometimes occurs early in treatment. Cross-resistance to zal-citabine, didanosine, and abacavir can occur simultaneously. Withdrawal of lamivudine in patients infected with both hepatitis B virus and HIV can cause a flare-up of hepatitis symptoms. 

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