Simple Quinolizidine Alkaloids Homopumiliotoxins

The pumiliotoxins, alio- and homopumiliotoxins, are alkaloids isolated from the skin of amphibians, such as neotropical frogs of the Dendrobatidae family, and are believed to serve as a chemical defence against predators. These natural products have interesting pharmacological properties, including myotonic and cardiotonic activities. 

HO Me Claisen-type condensation Intramolecular Heck reaction 

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