Simple hypercholesterolemia

Sirolimus is a potent immunosuppressive agent. To prevent thrombocytopenia and hypercholesterolemia, optimize efficacy, and reduce organ rejection, assays were developed to monitor concentrations of sirolimus in the whole blood of patients under treatment.40"12 Wallemacq et al.43 developed and validated a simple high-throughput HPLC-MS/MS method to routinely monitor sirolimus... 

Blache D, Bouthillier D, Davignon J (1983) Simple, reproducible procedure for selective measurement of lipoprotein lipase and hepatic lipase. Clin Chem 29 154-158 Bodamer OA, Bercovich D, Schlabach M, Ballantyne C, Zoch D, Beaudet AL (2002) Use of denaturing HPLC to provide efficient detection of mutations causing familial hypercholesterolemia. Clin Chem 48 1913-1918... 

The simple dioxolanone 309 has been prepared and has antidiabetic activity <2003W02550>, and the dioxolone structure 310 has been used as a pro-drug for pharmaceutically active amines R 2NH to which it is degraded in vivo <1995USP5466811>. Dioxolanone-containing compounds such as 311 have squalene synthetase and cholesterol synthetase inhibitory activity and can be used to treat hypercholesterolemia <2001JPP187789>. 

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