Signal Transmission Across the Plasma Membrane

Wild-type aL Intermediate affinity aL High affinity aL 

Vinogradova et al, 2002). NMR studies reveal a weak association between the integrin ant and /3s subunit cytoplasmic domains, and that this association is disrupted by mutations that are knovm to activate integrins, and by binding of the /3 subunit cytoplasmic domain to the cytoskeletal 

Mn and Ca ions are large magenta and yellow spheres, respectively. All putative metal coordinating sidechains and backbone carbonyl groups are shown, with N, O, and S atoms in blue, red, and yellow, respectively. The carbonyl and sidechain oxygens of S123 are marked O and O7, respectively. 

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